Trial document




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  DRKS00011795

Trial Description

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Title

Tactile Acuity in the area of ​​the cervical spine in migraine patients compared to healthy people

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Trial Acronym

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URL of the Trial

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Brief Summary in Lay Language

We investigate whether migraine patients are less sensitive to the perception of the head and the cervical spine compared to healthy subjects. We determine this with the aid of two-point discrimination.

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Brief Summary in Scientific Language

Migraine patients experience changes in the perception and central processing of tactile stimuli. Using imaging techniques, it has been shown that certain brain regions are more active in pain medications than others. Chronic pain, including migraine, is associated with a change in activity in the somatosensory cortex. Normally the activation of the somatosensory cortex follows a representative map, which is also referred to as a homunculus. Persistent pain can interfere with the differentiated allocation of nociceptive input and thus go hand in hand with a poorer sensory discriminatory capacity of the patient.
An evaluation of the patient's sensory discriminatory capacity allows two-point discrimination.
To date, studies on chronic lumbar back pain, such as the systematic review by Catley et al. 2014 demonstrate that changes in the somatosensory cortex correlate with the two point discrimination. With a statistically significant difference it was shown that the distances of the two point discrimination in patients with chronic lumbar back pain are greater than those in the control group. It is assumed that the training of the sensory perception ability can also be a sensible therapy measure. However, the studies on two point discrimination and migraine are deficient. To date, no studies have been identified that have investigated two point discrimination in the cervical spine of migraine patients. The two point discrimination is a cost-effective, practicable examination instrument that could be of great use in the diagnosis and treatment of migraine patients.
Against this background we developed the following question with the help of which the correlation between the changes in the somatosensory cortex in migraine patients and the two point discrimination should become clear.

Subject:
"Are migraine patients, compared to healthy people, worse in perceptual accuracy in the head and cervical spine, as measured by two-point discrimination?"

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Organizational Data

  •   DRKS00011795
  •   2017/06/26
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  •   yes
  •   Approved
  •   PV5011, Lokale Ethikkommission des Fachbereiches Psychologie und Bewegungswissenschaften der Universität Hamburg
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Secondary IDs

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Health Condition or Problem studied

  •   G43 -  Migraine
  •   M54.82 -  [generalization M54.8: Other dorsalgia]
  •   Healthy volunteers
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Interventions/Observational Groups

  •   Migraine patients in the intervention group (measurement of tactile Acuity using two point dicrimination)
  •   Healthy subjects in the control Group (measurement of tactile Acuity using two point dicrimination)
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Characteristics

  •   Non-interventional
  •   Other
  •   Non-randomized controlled trial
  •   Open (masking not used)
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  •   Other
  •   Basic research/physiological study
  •   Parallel
  •   N/A
  •   N/A
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Primary Outcome

Differentiation in perceptual accuracy between one and two points on the cervical spine with two Point discrimination

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Secondary Outcome

Differentiation in perceptual accuracy between one and two points at Hand with two Point discrimination

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Countries of Recruitment

  •   Germany
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Locations of Recruitment

  • University Medical Center 
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Recruitment

  •   Actual
  •   2017/06/28
  •   44
  •   Monocenter trial
  •   National
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Inclusion Criteria

  •   Both, male and female
  •   18   Years
  •   no maximum age
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Additional Inclusion Criteria

Intervention: Persons with a medically diagnosed migraine who are at least 18 years of age.
Control: Healthy persons, who are at least 18 years of age

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Exclusion Criteria

People with chronic pain (fibromyalgia, Sudeck disease), diabetic polyneuropathy, trigeminal neuralgia, cluster headache and acute influenza infection.

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Addresses

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    • Fachbereich Psychologie und Bewegungswissenschaften der Universität Hamburg
    • Ms.  Dr  Kerstin  Lüdtke 
    • Von-Melle-Park 5
    • 20146  Hamburg
    • Germany
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    • Universität Hamburg Fakultät für Psychologie und Bewegungswissenschaft Bewegungswissenschaft
    • Ms.  Dr.  Kerstin  Lüdtke 
    • Mollerstraße 10
    • 20148  Hamburg
    • Germany
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    • Universität Hamburg
    • Ms.  Janine  Schröder 
    • Hasenhöhe 27b
    • 22587  Hamburg
    • Germany
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Sources of Monetary or Material Support

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    • Fachbereich Psychologie und Bewegungswissenschaften der Universität Hamburg
    • Ms.  Dr.  Kerstin  Lüdtke 
    • Von-Melle-Park 5
    • 20146  Hamburg
    • Germany
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Status

  •   Recruiting ongoing
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Trial Publications, Results and other Documents

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