Trial document
DRKS00010804
Trial Description
Title
Genetic background of arterial hypertension
Trial Acronym
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URL of the Trial
Brief Summary in Lay Language
Goal of our investigation is it to find by gene analyses (DNA from a blood test) genetic variants (mutations) in patients with therapy resistant hypertension. It is known for a long time that hypertension is more prevalent in certain families. This is a reference that this illness has probably at least partial hereditary components, which we want to identify. So far only a small number at mutations in individual genes could be made responsible as an exclusive cause of hypertension in comparatively few families. This is above all because of the fact that hypertension can be a complex, polygenetic illness, which is further influenced by environmental factors. Furthermore genetic causes of hypertension have so far not sufficiently been explored. The proof of such changes in the genetic make-up is however of great importance in order to understand the impact of certain environmental factors and to develop purposeful treatments. This will permit conclusions regarding the illness processes in the respective patient.
Brief Summary in Scientific Language
To date approx. 25 monogenetic causes for arterial hypertension from the overlapping clinical spectra of cardiogenic, nephrogenic and endocrine phenotypes are known. With the help of new sequencing methods a relevant number of new monogenetic forms of hypertension have been identified in recent years. Considering the small number of known genetic forms of hypertension and the high frequency and clinical variability of arterial hypertension it is to be assumed that a very large genetic heterogeneity and a relevant number of yet unidentified monogenetic and complex-genetic forms of hypertension exist.
Goals of the present research project are:
i) the examination of specific risk variants for essential arterial hypertension in our well characterized patient cohort.
ii) the identification of new risk variants in candidate genes.
iii) the identification of so far unknown genetic causes of hypertension.
Do you plan to share individual participant data with other researchers?
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Description IPD sharing plan:
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Organizational Data
- DRKS00010804
- 2016/07/11
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- yes
- Approved
- 16-101, Ethik-Kommission der Medizinischen Fakultät der Universität zu Köln
Secondary IDs
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Health Condition or Problem studied
- I10.0 - [generalization I10: Essential (primary) hypertension]
Interventions/Observational Groups
-
Patients with therapy resistant hypertension
Intervention: genotyping of DNA from blood sample.
Characteristics
- Non-interventional
- Epidemiological study
- Single arm study
- Open (masking not used)
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- Uncontrolled/Single arm
- Diagnostic
- Single (group)
- N/A
- N/A
Primary Outcome
Prevalence of known genetic variants of hypertension.
Secondary Outcome
Genotypes of risk variants
Genepanel analysis
Exome (WES)- or genomesequencing (WGS)
Countries of Recruitment
- Germany
Locations of Recruitment
- University Medical Center
Recruitment
- Planned
- 2016/08/01
- 300
- Monocenter trial
- National
Inclusion Criteria
- Both, male and female
- 18 Years
- 99 Years
Additional Inclusion Criteria
Patients with therapy resistant hypertension.
Exclusion Criteria
Age < 18 yrs. Secondary causes of hypertension, pseudohypertension.
Addresses
-
start of 1:1-Block address primary-sponsor
- Universitäres Hypertoniezentrum Köln
- Mr. Prof. Dr. Hannes Reuter
- Kerpener Str. 62
- 50937 Köln
- Germany
end of 1:1-Block address primary-sponsorstart of 1:1-Block address contact primary-sponsor- 0221 47832401
- 0221 47832400
- hannes.reuter at uk-koeln.de
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end of 1:1-Block address contact primary-sponsor -
start of 1:1-Block address other
- Institut für HumangenetikUniversität zu Köln
- Mr. Dr. Bodo Beck
- Kerpener Str. 62
- 50937 Köln
- Germany
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end of 1:1-Block address contact other -
start of 1:1-Block address scientific-contact
- Universitäres Hypertoniezentrum Köln
- Mr. Prof. Dr. Hannes Reuter
- Kerpener Str. 62
- 50937 Köln
- Germany
end of 1:1-Block address scientific-contactstart of 1:1-Block address contact scientific-contact- 0221 47832401
- 0221 47832400
- hannes.reuter at uk-koeln.de
- [---]*
end of 1:1-Block address contact scientific-contact -
start of 1:1-Block address public-contact
- Universitäres Hypertoniezentrum Köln
- Mr. Prof. Dr. Hannes Reuter
- Kerpener Str. 62
- 50937 Köln
- Germany
end of 1:1-Block address public-contactstart of 1:1-Block address contact public-contact- 0221 47832401
- 0221 47832400
- hannes.reuter at uk-koeln.de
- [---]*
end of 1:1-Block address contact public-contact
Sources of Monetary or Material Support
-
start of 1:1-Block address materialSupport
- Universitäres Hypertoniezentrum Köln
- Mr. Prof. Dr. Hannes Reuter
- Kerpener Str. 62
- 50937 Köln
- Germany
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end of 1:1-Block address contact materialSupport
Status
- Recruiting planned
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Trial Publications, Results and other Documents
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