Trial document





This trial has been registered retrospectively.
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  DRKS00010666

Trial Description

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Title

Association of GNAS haplotypes and diastolic dysfunction in patients undergoing coronary artery bypass operations

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Trial Acronym

[---]*

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URL of the Trial

[---]*

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Brief Summary in Lay Language

The study looks about genetic predisposbility to diastolic dysfunction in patients under beta blockers who are undergoing a bypass heart operation
The goal of the study is to determine whether or not the diastolic function of the patients is genetic influenced

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Brief Summary in Scientific Language

Association of the GNAS haplotypes with the diastolic dysfunction in patients on beta blockers who are undergoing a CABG operation
The haplotypes are to be determined from 2 ml EDTA blood sample taken preoperatively
The diastolic evaluation intraoperative through the endoesophageal ECHO

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Organizational Data

  •   DRKS00010666
  •   2016/07/08
  •   [---]*
  •   yes
  •   Approved
  •   15-6633-BO, Ethik-Kommission der Medizinischen Fakultät der Universität Duisburg-Essen
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Secondary IDs

  • [---]*
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Health Condition or Problem studied

  •   I50.1 -  Left ventricular failure
  •   atrial fibrillation
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Interventions/Observational Groups

  •   Intraoperative transesophageal echocardiography (Before the cut - and after the Sternum suture)
    2 ml EDTA blood for SNP determination
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Characteristics

  •   Non-interventional
  •   Other
  •   Single arm study
  •   Open (masking not used)
  •   [---]*
  •   Uncontrolled/Single arm
  •   Prognosis
  •   Single (group)
  •   N/A
  •   N/A
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Primary Outcome

diastolic dysfunction assessment through TEE (transesophageal echocardiography), before the Skin cut and after the Sternum closure.

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Secondary Outcome

acute atrial fibrillation (within 1 week) / morbidity / mortality

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Countries of Recruitment

  •   Germany
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Locations of Recruitment

  • University Medical Center 
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Recruitment

  •   Actual
  •   2016/02/15
  •   250
  •   Monocenter trial
  •   National
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Inclusion Criteria

  •   Both, male and female
  •   45   Years
  •   85   Years
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Additional Inclusion Criteria

beta blocker / sinus rhythm / normal EF / Aortocoronary Bypass operation

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Exclusion Criteria

Valve abnormalities / atrial fibrillation / IABP or ECMO support

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Addresses

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    • Universitätsklinikum Essen
    • Hufelandstraße 55
    • 45147  Essen
    • Germany
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    • Universitätsklinikum Essen
    • Mr.  MBBCh  Saed  Omer 
    • Hufelandstraße 55
    • 45147  Essen
    • Germany
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    • Universitätsklinikum EssenKlinik für Anästhesie und Intensiv
    • Mr.  Saed  Omer 
    • Hufelandstraße 55
    • 45147  Essen
    • Germany
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Sources of Monetary or Material Support

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    • Universitätsklinikum Essen
    • Mr.  PD  Ulrich  Frey 
    • Hufelandstraße 55
    • 45147  Essen
    • Germany
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Status

  •   Recruiting ongoing
  •   [---]*
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Trial Publications, Results and other Documents

  • [---]*
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* This entry means the parameter is not applicable or has not been set.