Trial document




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  DRKS00007949

Trial Description

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Title

Driving the human motor system by sensory input

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Trial Acronym

SoM

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URL of the Trial

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Brief Summary in Lay Language

How sensations effects movements is not well understood. To be able to perform and learn a tasks the feedback from the movement is important. For example if you see that you shoot the soccer ball over the goal you will have to change the way you kick the ball. In rehabilitation this feedback is important as well, because people will have to learn a movement, like walking, again.
In this research project we will investigate in healthy subjects how this sensory information can effect performance on a task. We will investigate the influence of tactile sensation and vision on participants performance on detection tasks and on learning. We also test if, by improving the sensation with non-invasive brain stimulation, we can improve performance on different tasks.

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Brief Summary in Scientific Language

The effects of sensory stimulation on the motor system are not well understood at the moment. The sensory system includes different senses, such as touch, audition and vision. Sensory information, especially haptic and proprioceptive information, are essential to be able to interact with the environment (for example to interact with objects). They are however also important for movement control because these senses provide feedback on the movement. In the past most research focused on either the sensory system or the motor system. There is no doubt that sensory training leads to a significant improvement of the sensory perception. The increase in receptive fields after sensory training improve the response of the sensory cortex in reaction to stimulation and also improves the sensory discrimination behavior. However it is unclear how the sensory system can influence motor learning and motor functioning. We will investigate if sensory processing can be improved by brain stimulation. We will also investigate if the tactile information can influence and improve motor function, and also if the visual system can influence the motor system. We will measure neurophysiological parameters or behavioral performance.

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Organizational Data

  •   DRKS00007949
  •   2015/04/02
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  •   yes
  •   Approved
  •   KEK-ZH-Nr. 2014-0269, Kantonale Ethikkommission Zürich
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Secondary IDs

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Health Condition or Problem studied

  •   Basic research: The aim of this study is to investigate the influence of the human sensory system on the motor system
  •   Healthy subjects
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Interventions/Observational Groups

  •   The project includes electrophysiological markers (EEG EMG) and behavioural tests as well as modulation of these markers and tests with non-invasive transcranial current and magnetic stimulation (TCS, TMS, SMS)
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Characteristics

  •   Non-interventional
  •   Other
  •   Single arm study
  •   Open (masking not used)
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  •   Uncontrolled/Single arm
  •   Basic research/physiological study
  •   Single (group)
  •   N/A
  •   N/A
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Primary Outcome

Behavioural performance (reaction times, accuracy, detection thresholds) and physiological markers.

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Secondary Outcome

not applicable

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Countries of Recruitment

  •   Switzerland
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Locations of Recruitment

  • other 
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Recruitment

  •   Actual
  •   2016/10/05
  •   520
  •   Monocenter trial
  •   National
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Inclusion Criteria

  •   Both, male and female
  •   18   Years
  •   50   Years
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Additional Inclusion Criteria

Healthy subjects
Normal physical and mental health

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Exclusion Criteria

Known history of neurological and musculoskeletal disorders.
Pregnancy.
Metal implants in the body which would conduct current during non-invasive transcranial brain stimulation.

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Addresses

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    • NCM-Lab, ETH Zürich
    • Ms.  Prof. Dr.  Nicole  Wenderoth 
    • Winterthurerstrasse 190, Y36 M04
    • 8057  Zürich
    • Switzerland
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    • NCM-Lab, ETH Zürich
    • Ms.  Dr.  Maria  Willecke 
    • Winterthurerstrasse 190, Y36 M04
    • 8057  Zürich
    • Switzerland
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    • NCM-Lab, ETH Zürich
    • Ms.  Prof. Dr.  Nicole  Wenderoth 
    • Winterthurerstrasse 190, Y36 M04
    • 8057  Zürich
    • Switzerland
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Sources of Monetary or Material Support

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    • NCM-Lab, ETH Zürich
    • Ms.  Prof. Dr.  Nicole  Wenderoth 
    • Winterthurerstrasse 190, Y36 M04
    • 8057  Zürich
    • Switzerland
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Status

  •   Recruiting ongoing
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Trial Publications, Results and other Documents

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* This entry means the parameter is not applicable or has not been set.