Trial document





This trial has been registered retrospectively.
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  DRKS00005312

Trial Description

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Title

A promising approach to effectively reduce cramp susceptibility in human muscles

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Trial Acronym

[---]*

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URL of the Trial

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Brief Summary in Lay Language

Skeletal muscle cramps are characterized by an extraordinary high intramuscular tension. Since the latter is known to be an important anabolic signal for the musculature, the present study primarily aimed on inducing muscle cramps in order to evoke muscle growth. For that purpose the calf muscles of ten healthy male sport students were electrically stimulated twice a week in a shortened position, which induces muscle cramps. The opposite calf muscles were stimulated with the same protocol but were hindered from cramping by fixating the foot in a neutral position. Both legs of five healthy male sport students served as control. By chance we found out that the frequency that is necessary to induce a cramp was substantially increased after the intervention only in the lower legs that were simulated in a shortened position. Since this frequency is known to be correlated with the individual cramp susceptibility, the present stimulation protocol may be a promising approach to prevent muscle cramps.

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Brief Summary in Scientific Language

The primary aim of the present study was to take advantage of the extraordinary high intramuscular tension that is associated with muscle cramps in order to induce muscle growth. For that purpose the calf muscles of ten healthy male sport students were electrically stimulated twice a week (5sec on, 10sec off, 150µs impulse width, 30Hz above the individual cramp threshold frequency, 85% of the maximal stimulation energy) in a shortened position, inducing muscle cramps. The opposite calf muscles were stimulated with the same protocol but were hindered from cramping by fixating the foot in a neutral position. Both legs of five healthy male sport students served as control. By chance we found out that the cramp threshold frequency (CTF) was substantially increased after the intervention only in the lower legs that were stimulated in a shortened position. Since the CTF is known to be correlated with the individual cramp susceptibility, the present results may be a promising approach to prevent muscle cramps.

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Organizational Data

  •   DRKS00005312
  •   2013/09/24
  •   [---]*
  •   yes
  •   Approved
  •   47-2013, Ethikkommission der Deutschen Sporthochschule Köln
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Secondary IDs

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Health Condition or Problem studied

  •   R25.2 -  Cramp and spasm
  •   Healthy Volunteers
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Interventions/Observational Groups

  •   Stimulation of calf muscles in shortened muscle position (2x/ week over a period of 6 weeks)
  •   Stimulation of calf muscle in neutral muscle position (2x/ week over a period of 6 weeks)
  •   Control group without stimulation (observation period of 6 weeks)
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Characteristics

  •   Interventional
  •   [---]*
  •   Randomized controlled trial
  •   Open (masking not used)
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  •   Active control, No treatment
  •   Prevention
  •   Parallel
  •   N/A
  •   N/A
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Primary Outcome

Measuring the minimal electrical stimulation frequency that induces a muscle cramp (CTF) of the m. gastrocnemius medialis before, after three weeks and after the six week training intervention.

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Secondary Outcome

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Countries of Recruitment

  •   Germany
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Locations of Recruitment

  • other 
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Recruitment

  •   Actual
  •   2013/06/12
  •   15
  •   Monocenter trial
  •   National
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Inclusion Criteria

  •   Male
  •   20   Years
  •   35   Years
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Additional Inclusion Criteria

Male sport students between 20 and 35 years

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Exclusion Criteria

Any injuries of the musculosceletal system of the lower extremities within the last six months prior to the study and any cardiiovascular diseases

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Addresses

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    • Institut für Trainingswissenschaft und Sportinformatik Deutsche Sporthochschule Köln
    • Am Sportpark Müngersdorf 6
    • 50933  Köln
    • Germany
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    • Insitut für Trainingswissenschaft und SportinformatikDeutsche Sporthochschule Köln
    • Mr.  Dr. med. Dr. rer. nat.  Michael  Behringer 
    • Am Sportpark Müngersdorf 6
    • 50933  Köln
    • Germany
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    • Insitut für Trainingswissenschaft und SportinformatikDeutsche Sporthochschule Köln
    • Mr.  Dr. med. Dr. rer. nat.  Michael  Behringer 
    • Am Sportpark Müngersdorf 6
    • 50933  Köln
    • Germany
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Sources of Monetary or Material Support

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    • Institut für Trainingswissenschaft und Sportinformatik Deutsche Sporthochschule Köln
    • Am Sportpark Müngersdorf 6
    • 50933  Köln
    • Germany
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Status

  •   Recruiting complete, follow-up complete
  •   2013/08/09
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Trial Publications, Results and other Documents

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* This entry means the parameter is not applicable or has not been set.