Trial document





This trial has been registered retrospectively.
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  DRKS00004572

Trial Description

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Title

Treatment of non-fluent aphasia through melody, rhythm and formulaic language

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Trial Acronym

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URL of the Trial

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Brief Summary in Lay Language

When a stroke damages speech areas in the brain’s left hemisphere, sufferers often have severe difficulties speaking – a condition known as non-fluent aphasia. Sometimes the inability to speak spontaneously is permanent. However, there are frequent cases of aphasics who are able to sing song lyrics and formulaic phrases relatively fluently. Until now, this astonishing observation has been explained by the fact that the right brain hemisphere, which supports important functions of singing, remains intact. Singing was thought to stimulate areas in the right hemisphere, which would then assume the function for damaged left speech areas. A treatment method known as Melodic intonation therapy is based on this idea. This therapy includes three main components: singing, rhythmic speech and common, formulaic phrases ("How are you?"). The current study investigates the relative clinical efficacy of these components. 15 patients with chronic non-fluent aphasia receive either singing therapy, rhythmic therapy, or a standard speech therapy. Until now, it remains unclear whether or not singing conveys any therapeutic advantage over rhythmic speech in the treatment of non-fluent aphasia. The purpose of the present study is to address this question.

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Brief Summary in Scientific Language

Melodic intonation therapy includes a number of different elements, such as singing, rhythmic speech, and the use of common formulaic phrases. The current study investigates the relative clinical efficacy of these elements in a longitudinal repeated measures design. It should be explicitly noted that the study does not involve invasive or pharmacological interventions, nor does it involve neuroimaging; that is, the study is purely behavioral.

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Organizational Data

  •   DRKS00004572
  •   2012/11/29
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  •   yes
  •   Approved
  •   094-10-19042010, Ethikkommission an der Medizinischen Fakultät der Universität Leipzig
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Secondary IDs

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Health Condition or Problem studied

  •   F80.1 -  Expressive language disorder
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Interventions/Observational Groups

  •   Singing therapy (patients are singing formulaic phrases)

    Duration of treatment: 6 weeks with three one-hour long, weekly training sessions; follow-up measurements after 3 months following the end of each treatment
  •   Rhythmic therapy (patients are rhythmically speaking formulaic phrases)

    Duration of treatment: 6 weeks with three one-hour long, weekly training sessions; follow-up measurements after 3 months following the end of each treatment
  •   Standard therapy (speech therapy including common oral exercises in rehabilitative settings)

    Duration: 6 weeks with three one-hour long, weekly training sessions
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Characteristics

  •   Interventional
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  •   Non-randomized controlled trial
  •   Open (masking not used)
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  •   Active control
  •   Other
  •   Parallel
  •   N/A
  •   N/A
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Primary Outcome

Dependent variable: articulatory quality in non-fluent aphasic patients depending on treatment type; the patients' utterances are recorded by a microphone and analyzed with regard to articulatory errors (phonetic and phonematic)

Recordings take place before and after each treatment (singing therapy, rhythmic therapy, standard therapy); additional follow-up recordings after 3 months after the end of each treatment

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Secondary Outcome

/

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Countries of Recruitment

  •   Germany
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Locations of Recruitment

  • Medical Center 
  • Medical Center 
  • Medical Center 
  • Medical Center 
  • other 
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Recruitment

  •   Actual
  •   2010/05/01
  •   15
  •   Multicenter trial
  •   National
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Inclusion Criteria

  •   Both, male and female
  •   35   Years
  •   75   Years
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Additional Inclusion Criteria

Non-fluent aphsia; German native-speaker; right-handed; aged 35 to 75 years; intact hearing; at least six months post infarction at the time of testing

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Exclusion Criteria

pre-morbid history of neurological or psychiatric impairments including dementia

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Addresses

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    • Max-Planck-Institut für Kognitions- und Neurowissenschaften
    • Mr.  PD Dr.  Stefan  Geyer 
    • Stephanstraße 1A
    • 04103  Leipzig
    • Germany
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    • Max-Planck-Institut für Kognitions- und Neurowissenschaften
    • Mr.  Benjamin  Stahl 
    • Stephanstraße 1A
    • 04103  Leipzig
    • Germany
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    • Max-Planck-Institut für Kognitions- und Neurowissenschaften
    • Mr.  Benjamin  Stahl 
    • Stephanstraße 1A
    • 04103  Leipzig
    • Germany
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Sources of Monetary or Material Support

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    • Max-Planck-Institut für Kognitions- und Neurowissenschaften International Max Planck Research School on Neuroscience of Communication
    • 04103  Leipzig
    • Germany
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Status

  •   Recruiting complete, follow-up complete
  •   2012/11/01
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Trial Publications, Results and other Documents

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