Trial document





This trial has been registered retrospectively.
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  DRKS00004209

Trial Description

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Title

Age-effects in the determinants of performance, nutrition and health in track and field Master Athletes and control subjects

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Trial Acronym

MAC

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URL of the Trial

[---]*

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Brief Summary in Lay Language

Field study at the European Veteran's Athletic Championships 2012 in Zittau. Participating athletes are the subjects of the study. There is furthermore a control group for the muscle biopsies. The central topic of the study is research on the factors influence the drop in performance of the musculo-skeletal system during ageing. There are several experiments to be performed during this study:
- jump and hopping tests
- Heat exchange, oxygen delivery and consumption limitations of muscle function
- Muscle biopsies and Blood samples for determination of oxidative stress, systemic inflam-mation, insulin, glucose and lipoproteins
- bone density measurements
- muscle mass tests
- Resting metabolic rate (RMR) and energy needs of master athletes
- Incidence of injuries and medical emergencies in master athletes during competition

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Brief Summary in Scientific Language

Field study at the European Veteran's Athletic Championships 2012 in Zittau. Participating athletes are the subjects of the study. The central topic of the study is research on the factors influence the drop in performance of the musculo-skeletal system during ageing. There are several experiments to be performed during this study:
- jump and hopping tests
- Heat exchange, oxygen delivery and consumption limitations of muscle function
- Muscle biopsies and Blood samples for determination of oxidative stress, systemic inflam-mation, insulin, glucose and lipoproteins
- bone density measurements (pQCT)
- muscle mass tests (sarcopenia)
- Resting metabolic rate (RMR) and energy needs of master athletes
- Incidence of injuries and medical emergencies in master athletes during competition

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Organizational Data

  •   DRKS00004209
  •   2013/01/07
  •   [---]*
  •   yes
  •   Approved
  •   2012157, Ethikkommission der Ärztekammer Nordrhein
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Secondary IDs

  • [---]*
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Health Condition or Problem studied

  •   Ageing
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Interventions/Observational Groups

  •   Athletes participating in the 2012 European Veteran Athletic Championships. Depending on subject profile and consent, several tests were performed in the study.
  •   The Muscle Biopsy control group was not tested.
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Characteristics

  •   Non-interventional
  •   Other
  •   Non-randomized controlled trial
  •   Open (masking not used)
  •   [---]*
  •   Other
  •   Basic research/physiological study
  •   Other
  •   N/A
  •   N/A
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Primary Outcome

Muscle force measured once with jump- and hopping tests, Vo2max measured once by spiroergometry, determination of muscle mass once with bioimpedance, basal metabolic rate measured once by a fasting-measurement, assessment of injuries and emergencies by data collecion with cards.

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Secondary Outcome

[---]*

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Countries of Recruitment

  •   Germany
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Locations of Recruitment

  • other 
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Recruitment

  •   Actual
  •   2012/08/16
  •   150
  •   Monocenter trial
  •   National
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Inclusion Criteria

  •   Both, male and female
  •   35   Years
  •   110   Years
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Additional Inclusion Criteria

There are individual criteria for each test:

1. Jump and hopping tests: Any master athlete

2. Heat exchange, oxygen delivery and consumption limitations of muscle function: Any Master Athlete.

3. Blood samples for determination of oxidative stress, systemic inflammation, lipoprotein profile, glucose, insulin: Any Master Athlete

4. Muscle Biopsy (Biopsy): Any master athlete

5. Follow-up of bone density measurements (pQCT): Athletes who have already participated in our pQCT-study in the past

6. Sarcopenia: Any master athlete

7. Resting metabolic rate: Any master athlete

8. Incidence of injuries and medical emergencies in master athletes during competition: Any master athlete with an injury during the competition

9. Muscle Biopsy Control group (DLR Cologne): No regular training for a specific sport on a competition level. As this is a control group, participants will be matched with the athletes.

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Exclusion Criteria

There are individual criteria for each test:

1. Jump and hopping tests: none

2. Heat exchange, oxygen delivery and consumption limitations of muscle function: Neuromuscular disorders
Cardiovascular history including:
o previous myocardial infarction
o previous stroke
o known cardiac valve insufficiencies
o arrhythmias
major surgery in the last two years
organ transplants

3. Blood samples for determination of oxidative stress, systemic inflammation, lipoprotein profile, glucose, insulin: Increased bleeding tendency (hemophilia, regular use of anticoagulants)

4. Muscle Biopsy (Biopsy): Increased bleeding tendency (hemophilia, regular use of anticoagulants), history of intolerance to local anesthetics, neuromuscular disorders, cardiovascular history including:
o previous myocardial infarction
o previous stroke
o known cardiac valve insufficiencies
o arrhythmias
major surgery in the last two years
organ transplants

5. Follow-up of bone density measurements (pQCT): Athletes who have not participated in our study in the past, pregnant athletes

6. Sarcopenia: Athletes with a cardiac pacemaker or an implantable cardioverter defibrillator

7. Resting metabolic rate: none

8. On location: Incidence of injuries and medical emergencies in master athletes during competition: none

9. Muscle Biopsy Control group (DLR Cologne): As this is a control group, participants will be matched with the athletes. Otherwise same exclusion criteria as in test station 3.

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Addresses

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    • Deutsches Zentrum für Luft- und Raumfahrt Institut für Luft- und Raumfahrtmedizin Weltraumphysiologie
    • Mr.  Prof. Dr. med.  Jörn  Rittweger 
    • Linde Höhe
    • 51147  Köln
    • Germany
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    • Universitätsklinikum Erlangen
    • Maximiliansplatz 2
    • 91054  Erlangen
    • Germany
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    • Deutsches Zentrum für Luft- und Raumfahrt Institut für Luft- und Raumfahrtmedizin Weltraumphysiologie
    • Mr.  Prof. Dr. med.  Jörn  Rittweger 
    • Linde Höhe
    • 51147  Köln
    • Germany
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    • Deutsches Zentrum für Luft- und Raumfahrt Institut für Luft- und Raumfahrtmedizin Weltraumphysiologie
    • Mr.  Prof. Dr. med.  Jörn  Rittweger 
    • Linde Höhe
    • 51147  Köln
    • Germany
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Sources of Monetary or Material Support

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    • Deutsches Zentrum für Luft- und Raumfahrt Institut für Luft- und Raumfahrtmedizin Weltraumphysiologie
    • Mr.  Prof. Dr. med.  Jörn  Rittweger 
    • Linde Höhe
    • 51147  Köln
    • Germany
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Status

  •   Recruiting complete, follow-up complete
  •   2012/08/26
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Trial Publications, Results and other Documents

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* This entry means the parameter is not applicable or has not been set.