Trial document




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  DRKS00004202

Trial Description

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Title

Comparrison of different kinds of substance abuse with respect to neuropsychological and neurobiological aspects and relevant personality traits.

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Trial Acronym

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URL of the Trial

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Brief Summary in Lay Language

Drug addictions are influenced by a variety of factors that could not be integrated in a uniform model so far. Besides environmental factors genetic influences play a pivotal role. Empirical findings from addiction research could identify factors that are crucial for all kinds of addictions. Nevertheless, it is an open question why someone becomes alcohol and not cannabis or heroin addicted. It is suggested that there exist factors that are specific for a distinct form of addiction. The starting point for identifying these factors are clinical symptoms (e.g. lack of impulse control or delay of gratification, the neglect of negative behavioral outcomes etc.) or the pharmacodynamic effects of the respective drug under investigation (e.g. stimulation or blockade of specific receptors in the brain). In order to characterize the spectrum of potential factors predisposing for addiction, the present study investigates participants by means of questionnaire measures, experimental tests and genetic analyses. The focus of the present research program is the identification of those factors that are common or specific for alcohol and cannabis addiction.

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Brief Summary in Scientific Language

The etiology of alcohol as well as of cannabis addiction is multi-factorial, although genetic factors play a prominent role. Given the high prevalence rates of both forms of addiction and their in part overlapping risk factors, it is aimed to identify predictors in the sense of discriminant and congruent validity. Potential predictors are recruited out of the domains of (1) cognitive functions, (2) affective-motivational traits, and (3) genetic markers. The assessment of cognitive functioning will be conducted by a Go/Nogo-Paradigm, the trail-making-test, a STROOP-task and the IOWA-Gambling-Task (a game inducing gains and losses). Affective-motivational aspects are assessed by means of one- and multi-dimensional self-assessment instruments. The validation of genetic markers will be done by genotyping candidate genes for addiction.

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Organizational Data

  •   DRKS00004202
  •   2012/08/02
  •   [---]*
  •   yes
  •   Approved
  •   (es wird keine Vorlagennummer bei der lokalen Ethikkommission vergeben), Ethikkommission am Institut für Psychologie, Rheinische Friedrich-Wilhelms-Universität Bonn
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Secondary IDs

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Health Condition or Problem studied

  •   F10.2 -  Mental and behavioural disorders due to use of alcohol; Dependence syndrome
  •   F12.2 -  Mental and behavioural disorders due to use of cannabinoids; Dependence syndrome
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Interventions/Observational Groups

  •   alcohol dependent patients (abstinent at the time point of investigation) – participants will be investigated by means of neuropsychological tests, genetic analyses and questionnaires.
  •   cannabis dependent patients (abstinent at the time point of investigation) – participants will be investigated by means of neuropsychological tests, genetic analyses and questionnaires.
  •   healthy matched controls recruited according to the socio-demographic attributes of patient groups (1,2) – controls will be investigated by means of neuropsychological tests, genetic analyses and questionnaires.
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Characteristics

  •   Non-interventional
  •   Other
  •   Non-randomized controlled trial
  •   Open (masking not used)
  •   [---]*
  •   Other
  •   Basic research/physiological study
  •   Parallel
  •   N/A
  •   N/A
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Primary Outcome

The aim of the present study is the identification of genetic (polymorphisms on genes relevant for addiction), neuropsychological (trail-making-test, IOWA-Gambling-Task, Go-Nogo-Task, STROOP-Test) and affective-motivational predictors (questionnaires, e.g. TCI) that are able to discriminate cannabis addicts, alcohol addicts (both groups at least 10 days abstinent) and controls or that are common for drug addictions in general.

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Secondary Outcome

Not relevant. However, it is imaginable that further studies make use out of the results of the present study for the therapy and prevention of substance abuse disorders in the future.

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Countries of Recruitment

  •   Germany
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Locations of Recruitment

  • Medical Center 
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Recruitment

  •   Planned
  •   2012/09/02
  •   200
  •   Monocenter trial
  •   National
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Inclusion Criteria

  •   Both, male and female
  •   18   Years
  •   70   Years
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Additional Inclusion Criteria

cases/patients: ICD-10 F10.2 or F12.2, written informed consent


controls: no clinical diagnosis according to ICD-10 F1, written informed consent

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Exclusion Criteria

acute intoxication by psychotropic substances, alcohol- or cannabis consumption within the last 10 days (in advance of the testing), sedating drugs, insufficient knowledge of the German language

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Addresses

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    • Uni Bonn
    • Mr.  Prof. Dr.  Martin  Reuter 
    • Kaiser-Karl-Ring 9
    • 5311  Bonn
    • Germany
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    • Rheinische Friedrich-Wilhelms-Universität Bonn, Institut für Psychologie
    • Mr.  Prof. Dr. Dipl. Psych.  Martin  Reuter 
    • Kaiser-Karl-Ring 9
    • 53111  Bonn
    • Germany
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    • Rheinische Friedrich-Wilhelms-Universität Bonn, Institut für Psychologie
    • Mr.  Prof. Dr. Dipl. Psych.  Martin  Reuter 
    • Kaiser-Karl-Ring 9
    • 53111  Bonn
    • Germany
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Sources of Monetary or Material Support

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    • Uni Bonn
    • Mr.  Prof. Dr.  Martin  Reuter 
    • Kaiser-Karl-Ring 9
    • 5311  Bonn
    • Germany
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Status

  •   Recruiting planned
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Trial Publications, Results and other Documents

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* This entry means the parameter is not applicable or has not been set.