Trial document





This study has been imported from ClinicalTrials.gov without additional data checks.
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  DRKS00004122

Trial Description

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Title

Investigation of the Suburothelial Myofibroblast Network and of Smooth Muscle Function and Control in the Continent and Incontinent Human Urinary Outflow Tract

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Trial Acronym

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URL of the Trial

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Brief Summary in Lay Language

The aim is to find out if adreno-muscarinic synergy is present also in human tissues of the
urinary outflow tract that have a dual adrenergic-muscarinic receptor fitting. To further
characterise morphology and function of the suburothelial myofibroblast network in the human
bladder outlet.

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Brief Summary in Scientific Language

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Organizational Data

  •   DRKS00004122
  •   2012/10/11
  •   2010/10/22
  •   yes
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Secondary IDs

  •   NCT01227447  (ClinicalTrials.gov)
  •   RO 3589/2-1  (Ludwig-Maximilians - University of Munich)
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Health Condition or Problem studied

  •   Incontinence, Overactive Bladder, Stress Urinary Incontinence
  •   N32.8 -  Other specified disorders of bladder
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Interventions/Observational Groups

  • [---]*
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Characteristics

  •   Non-interventional
  •   Observational study
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  •   N/A
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Primary Outcome

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Secondary Outcome

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Countries of Recruitment

  •   Germany
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Locations of Recruitment

  •  
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Recruitment

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  •   2010/01/31
  •   200
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Inclusion Criteria

  •   Both, male and female
  •   18   Years
  •   no maximum age
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Additional Inclusion Criteria

Tissue will be collected from the operation theatre only after having obtained the
patient´s consent and in strictest accordance with histopathological requirements, i.e.
after assessment of resection margins. It might be necessary to retrieve the tissue from
the pathologist after first pathological assessment is completed. Tissue will be placed in
Tyrode´s solution, gassed with 95 % O2 and 5 % CO2, for functional and RT-PCR or Western
blot experiments, or in OCT (optimal cutting temperature) compound, snap-frozen in liquid
nitrogen, and stored in a -80°C freezer until cutting for immunohistochemical experiments.

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Exclusion Criteria

[---]*

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Addresses

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    • Ludwig-Maximilians - University of Munich
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    • LMU Munich
    • Alexander Roosen, PD Dr 
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    • Alexander Roosen, MD 
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Sources of Monetary or Material Support

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    • Bitte wenden Sie sich an den Sponsor / Please refer to primary sponsor
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Status

  •   Recruiting ongoing
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Trial Publications, Results and other Documents

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The parameters in ClinicalTrials.gov and DRKS are not identical. Therefore the data import from ClinicalTrials.gov required adjustments. For full details please see the DRKS FAQs .
  •   6
  •   2016/01/14


* This entry means the parameter is not applicable or has not been set.