Trial document





This trial has been registered retrospectively.
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  DRKS00003577

Trial Description

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Title

Cortical integration of multimodal object and spatial information; Sub-project: Psychophysical experiments with patients with occipital cortical lesions

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Trial Acronym

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URL of the Trial

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Brief Summary in Lay Language

Patients who are blind in one half of their visual field benefit from hearing auditory stimuli on the affected side. After passively hearing tones for an hour, their perception of light stimuli in the blind half of their visual field improved significantly. Neural pathways that simultaneously process information from different senses may be responsible for this effect. To investigate the effectiveness of the auditory stimuli, the research team carried out a sight test before and after the acoustic stimulation. The task of the ten patients was to determine the position of light flashes in the healthy and in the blind field of vision. While performance was stable in the intact half of their field of vision, the number of correct answers in the blind half increased after the auditory stimulation. This effect lasted for 1.5 hours.

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Brief Summary in Scientific Language

Techniques employed in rehabilitation of visual field disorders such as hemianopia are usually based on either visual or audio-visual stimulation and patients have to perform a training task. Here we present results from a completely different, novel approach that was based on passive unimodal auditory stimulation. Ten patients with either left or right-sided pure hemianopia (without neglect) received one hour of unilateral passive auditory stimulation on either their anopic or their intact side by application of repetitive trains of sound pulses emitted simultaneously via two loudspeakers. Immediately before and after passive auditory stimulation as well as after a period of recovery, patients completed a simple visual task requiring detection of light flashes presented along the horizontal plane in total darkness. The results showed that one-time passive auditory stimulation on the side of the blind, but not of the intact, hemifield of patients with hemianopia induced an improvement in visual detections by almost 100% within 30 min after passive auditory stimulation. This enhancement in performance was reversible and was reduced to baseline 1.5 h later. A non-significant trend of a shift of the visual field border toward the blind hemifield was obtained after passive auditory stimulation. These results are compatible with the view that passive auditory stimulation elicited some activation of the residual visual pathways, which are known to be multisensory and may also be sensitive to unimodal auditory stimuli as were used here.

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Organizational Data

  •   DRKS00003577
  •   2012/02/27
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  •   yes
  •   Approved
  •   2551, Ethik-Kommission der Medizinischen Fakultät der Ruhr-Universität Bochum
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Secondary IDs

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Health Condition or Problem studied

  •   H53.4 -  Visual field defects
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Interventions/Observational Groups

  •   Ten patients with either left or right-sided pure hemianopia (without neglect) received one hour of unilateral passive auditory stimulation on either their anopic or their intact side by application of repetitive trains of sound pulses emitted simultaneously via two loudspeakers. Immediately before and after passive auditory stimulation as well as after a period of recovery, patients completed a simple visual task requiring detection of light flashes presented from light-emitting diods along the horizontal plane in total darkness.

    The acoustic stimulus used consisted of band-pass-filtered frozen noise (lower cutoff frequency 2 kHz; upper cutoff frequency 11 kHz). Stimuli were trains of ten sound bursts. Each stimulus train had an overall duration of 960 ms; single sound bursts had a duration of 60 ms with triangular envelope (onset/offset time 30 ms) and were presented at a rate of 10 Hz. The stimulus trains were presented at a rate of one per 5 s (interstimulus interval 4.04 s). Stimuli were always emitted with incoherent waveforms simultaneously from two loudspeakers located 14° and 76° on the same side. Sound stimuli were presented at a sound-pressure level of 60 dB(A).
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Characteristics

  •   Interventional
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  •   Single arm study
  •   Open (masking not used)
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  •   Uncontrolled/Single arm
  •   Basic research/physiological study
  •   Single (group)
  •   N/A
  •   N/A
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Primary Outcome

Psychophysical measurement of the frequency of correct responses to visual stimuli prior to and after repetitive passive auditory stimulation.

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Secondary Outcome

-

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Countries of Recruitment

  •   Germany
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Locations of Recruitment

  • other 
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Recruitment

  •   Actual
  •   2005/06/12
  •   10
  •   Monocenter trial
  •   National
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Inclusion Criteria

  •   Both, male and female
  •   18   Years
  •   70   Years
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Additional Inclusion Criteria

homonymous hemianopia

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Exclusion Criteria

hearing impairments, neglect, other neurological disorders

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Addresses

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    • Ruhr-Universität Bochum, Fakultät für Psychologie
    • Mr.  PD Dr.  Jörg  Lewald 
    • Universitätsstr. 150
    • 44780  Bochum
    • Germany
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    • Ruhr-Universität Bochum, Fakultät für Psychologie
    • Mr.  PD Dr.  Jörg  Lewald 
    • Universitätsstr. 150
    • 44780  Bochum
    • Germany
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    • Ruhr-Universität Bochum, Fakultät für Psychologie
    • Mr.  PD Dr.  Jörg  Lewald 
    • Universitätsstr. 150
    • 44780  Bochum
    • Germany
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Sources of Monetary or Material Support

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    • Deutsche Forschungsgemeinschaft
    • Kennedyallee 40
    • 53175  Bonn
    • Germany
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Status

  •   Recruiting complete, follow-up complete
  •   2011/07/02
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Trial Publications, Results and other Documents

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