Trial document




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  DRKS00003544

Trial Description

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Title

Neuro-mechanical deficits in chronic ankle instability

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Trial Acronym

Neuro-Mech CAI

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URL of the Trial

[---]*

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Brief Summary in Lay Language

Lateral ankle sprains may lead to the development of a chronic ankle instability, which may be sub-devided in mechanical and functional ankle instability.
The aim of the present study is to determine differences in neuromuscular control between persons with functional, mechanical, combined, or without instability.
Therefore, ankle joint motion, muscle activation and muscle mechanics will be determined in two different conditions. In the first condition a predetermined supination of the ankle joint will be applied during walking and hopping. In the second condition the subjects will perform sport specific movements like running with a change of direction or landings.
It is hypothesized that subjects with chronic ankle instability will show an impaired neuromuscular ankle joint control compared to controls.
Based on an amendment the following changes were made: The group with a pure mechanical instability was deleted.

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Brief Summary in Scientific Language

Lateral ankle sprains may lead to the development of a chronic ankle instability, which may be sub-devided in mechanical and functional ankle instability.
The aim of the present study is to determine differences in neuromuscular control between persons with functional, mechanical, combined, or without instability in a cross-sectional study.
Therefore, ankle joint motion (3D stereophotometry), muscle activation (electromyography) and muscle mechanics (ultrasound) will be determined in two different conditions. In the first condition a predetermined supination of the ankle joint (15° plantarflexion + 24° inversion) will be applied during walking and hopping. In the second condition the subjects will perform sport specific movements like running with a change of direction or landings.
The hypotheses are:
1. Subjects with chronic ankle instability will show an impaired neuromuscular ankle joint control compared to controls.
2. The neuro-mechanical ankle joint control is different between persons with a pure functional instability and persons with functional and mechanical ankle instability in combination.

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Organizational Data

  •   DRKS00003544
  •   2012/03/06
  •   [---]*
  •   yes
  •   Approved
  •   29/12, Ethik-Kommission der Albert-Ludwigs-Universität Freiburg
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Secondary IDs

  • [---]*
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Health Condition or Problem studied

  •   S93 -  Dislocation, sprain and strain of joints and ligaments at ankle and foot level
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Interventions/Observational Groups

  •   Subjects with a functional ankle instability will be analysed using stereophotogrammetry, electromyography, and sonography.
  •   Subjects with a combined functional and mechanical ankle instability will be analysed using stereophotogrammetry, electromyography, and sonography.
  •   Subjects without an ankle instability (controls) will be analysed using stereophotogrammetry, electromyography, and sonography.
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Characteristics

  •   Non-interventional
  •   Other
  •   Non-randomized controlled trial
  •   Open (masking not used)
  •   [---]*
  •   Other
  •   Basic research/physiological study
  •   Parallel
  •   N/A
  •   N/A
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Primary Outcome

Comparison of the neuromuscular ankle joint control between the three groups by the means of stereophotogrammetry and electromyography at one time point.

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Secondary Outcome

Comparison of the muscle mechanics between the three groups using ultrasound measurements at one time point.

Classification of the four groups by the means of two questionnaires (FAAM-G and CAIT) at one time point.

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Countries of Recruitment

  •   Germany
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Locations of Recruitment

  • other 
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Recruitment

  •   Actual
  •   2012/04/01
  •   120
  •   Monocenter trial
  •   National
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Inclusion Criteria

  •   Both, male and female
  •   18   Years
  •   35   Years
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Additional Inclusion Criteria

physically active male and female subjects participating in sports with a high risk of lateral ankle sprains (soocer, handball, basketball, volleyball)
age: 18-35 years
All subjects have no orthopaedic and neurologic disorders. In addition, subjects of the reference group have no impairments in ankle joint control during daily activity and during exercise. The subjects with chronic ankle instability have a injury history of at least 2 lateral ankle sprains in the last 2 years.

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Exclusion Criteria

Subjects (functional instable; mechanical and functional combined)
- orthopaedic and neurological disorders
- any surgery at the ankle joint and the foot
- last ankle sprain in a period of less than three month before the measurement
- any acute impairments due to a recent lateral ankle sprain

Healthy Controls:
- orthopaedic and neurological disorders
- any surgery at the ankle joint and the foot
- any lateral ankle sprain in the past

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Addresses

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    • Institut für Sport und Sportwissenschaft Albert-Ludwigs-Universität Freiburg
    • Mr.  Prof. Dr.  Albert  Gollhofer 
    • Schwarzwaldstraße 175
    • 79117  Freiburg
    • Germany
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    •   [---]*
    •   [---]*
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    •   [---]*
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    • Institut für Sport und Sportwissenschaft Albert-Ludwigs-Universität Freiburg
    • Mr.  Dr.  Dominic  Gehring 
    • Schwarzwaldstraße 175
    • 79117  Freiburg
    • Germany
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    • Institut für Sport und Sportwissenschaft Albert-Ludwigs-Universität Freiburg
    • Mr.  Dr.  Dominic  Gehring 
    • Schwarzwaldstraße 175
    • 79117  Freiburg
    • Germany
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Sources of Monetary or Material Support

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    • Bundesinstitut für Sportwissenschaften
    • Postfach 170148
    • 53027  Bonn
    • Germany
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    •   [---]*
    •   [---]*
    •   [---]*
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Status

  •   Recruiting complete, follow-up complete
  •   2012/11/30
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Trial Publications, Results and other Documents

  •   Gehring D, Faschian K, Lauber B, Lohrer H, Nauck T, Gollhofer A. Mechanical instability destabilises the ankle joint directly in the ankle-sprain mechanism. Br J Sports Med. 2014 Mar;48(5):377-82.
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* This entry means the parameter is not applicable or has not been set.