Trial document




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  DRKS00003484

Trial Description

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Title

High resolution functional imaging: a method-comparison

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Trial Acronym

HiRes

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URL of the Trial

[---]*

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Brief Summary in Lay Language

The study compares two different measuring methods. Participants will repeatedly process a task during a functional magnetic resonance imaging (fMRI) examination.
The spatial resolution of fMRI methods lies between about 2 and 4 millimeters. Some brain structures are of this scale or even beneath, which results in inaccurate representation of these brain areas. New methods are able to acquire data sets with about 1 millimeter resolution, which enables the representation of very small brain structures. Disadvantages of these methods are stronger artifacts.
The aim of the study is the establishment of a measuring method, which enables the representation of small brain structures with minimal artifacts.
For that reson participants will process the fMRI task twice during different measuring sequences. The two measuring methods will be compared by statistical analyses.

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Brief Summary in Scientific Language

The study compares two different measuring methods in functional magnetic resonance imaging (fMRI) using echo planar imaging (EPI) techniques. In fMRI the partial volume effect results in artefacts when examining small brain structures. The spatial resolution of fMRI methods lies between about 2 and 4 millimeters. Some brain structures are of this scale or even beneath, which results in inaccurate representation of these brain areas. Furthermore, adjacent small brain regions might be badly classified. New methods are able to acquire data sets with about 1 millimeter resolution, which enables the representation and correct classification of very small brain structures. Disadvantages of these methods are stronger artifacts. The aim of the study is the establishment of a measuring method, which enables the representation of small brain structures with minimal artifacts.
During a functional magnetic resonance imaging (fMRI) examination participants will repeatedly process a task examining motivational behavior and reward processing. The task will be presented twice during different measuring sequences (resolution 96x96 and 192x192, respectively). The two measuring methods will be compared by statistical analyses using the fMRI analysis software SPM.

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Organizational Data

  •   DRKS00003484
  •   2012/01/26
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  •   yes
  •   Approved
  •   Aktenzeichen 2011-390N-MA, Medizinische Ethik-Kommission II Medizinische Fakultät Mannheim der Universität Heidelberg
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Secondary IDs

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Health Condition or Problem studied

  •   not applicable (methodological study in healthy controls)
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Interventions/Observational Groups

  •   healthy controls, fMRI mesurement with two different measurement protocols (resolution 96x96 versus 192x192)
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Characteristics

  •   Non-interventional
  •   Other
  •   Single arm study
  •   Open (masking not used)
  •   [---]*
  •   Uncontrolled/Single arm
  •   Basic research/physiological study
  •   Single (group)
  •   N/A
  •   N/A
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Primary Outcome

Development of optimal fMRT examination methods to study small brain regions

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Secondary Outcome

no secondary outcome

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Countries of Recruitment

  •   Germany
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Locations of Recruitment

  • University Medical Center 
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Recruitment

  •   Actual
  •   2012/01/17
  •   20
  •   Monocenter trial
  •   National
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Inclusion Criteria

  •   Both, male and female
  •   18   Years
  •   65   Years
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Additional Inclusion Criteria

Adequate ability to communicate with the investigators, to answer questions orally and in written form.
Ability to agree to participate after written informed consent

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Exclusion Criteria

contraindications for magnetic resonance imaging examinations
pregancy (positive pregnancy test)
uncorrectable reduced visual or auditory acuity

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Addresses

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    • Zentralinstitut für Seelische Gesundheit Klinik für Abhängiges Verhalten und Suchtmedizin
    • Mr.  Prof. Dr. med.  Karl  Mann 
    • J5
    • 68159  Mannheim
    • Germany
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    • Zentralinstitut für Seelische Gesundheit Klinik für Abhängiges Verhalten und Suchtmedizin
    • Ms.  PD Dr. sc. hum.  Sabine  Vollstaedt-Klein 
    • J 5
    • 68159  Mannheim
    • Germany
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    • Zentralinstitut für Seelische Gesundheit Klinik für Abhängiges Verhalten und Suchtmedizin
    • Ms.  PD Dr. sc. hum.  Sabine  Vollstädt-Klein 
    • J5
    • 68199  Mannheim
    • Germany
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Sources of Monetary or Material Support

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    • Zentralinstitut für Seelische Gesundheit, Klinik für Abhängiges Verhalten und Suchtmedizin
    • Mr.  Prof. Dr.  Karl  Mann 
    • J 5
    • 68159  Mannheim
    • Germany
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Status

  •   Recruiting complete, follow-up complete
  •   2012/03/27
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Trial Publications, Results and other Documents

  •   Domsch S, Zapp J, Schad L R, Nees F, Hill H, Hermann D, Mann K and Vollstädt-Klein S (2015) Optimized Protocol for High Resolution Functional Magnetic Resonance Imaging at 3T using Single-Shot Echo Planar Imaging. Journal of Neuroscience Methods. 239:170-182. doi:10.1016/j.jneumeth.2014.10.014
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* This entry means the parameter is not applicable or has not been set.